ATC CODE N06AX05

TRAZODONE

Τραζοδόνη

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)

Κύρια Ένδειξη

For the treatment of depression.

Χρόνος Ημιζωής

Undergoesbiphasiceliminationwithaninitialphaset1/2αof3-6handaterminalphaset1/2βof5-9h.

Undergoes biphasic elimination with an initial phase t1/2 α of 3-6 hours and a terminal phase t1/2 β of 5-9 hours.

Σύνδεση Πρωτεϊνών

89-95% bound to plasma proteins in vitro

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Μηχανισμός Δράσης

Trazodone binds at 5-HT2 receptor, it acts as a serotonin agonist at high doses and a serotonin antagonist at low doses. Like fluoxetine, trazodone's …