Αντιβιοτικά

ATC CODE A06AX06

TEGASEROD

Τεγασερόδη

Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug …

Chemical structure of TEGASEROD

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

Tegaserod is a 5-HT4 agonist manufactured by Novartis and used for the management of irritable bowel syndrome and constipation. Its use was the only drug approved by the United States Food and Drug Administration to help relieve the abdominal discomfort, bloating and constipation associated with irritable bowel syndrome. On March 30, 2007, the U.S. Food and Drug Administration requested that Novartis withdraw Zelnorm from shelves. The FDA alleges a relationship between prescriptions of the drug and increased risks of heart attack or stroke. [Wikipedia]

Κύρια Ένδειξη

Provides relief from the symptoms of irritable bowel syndrome including chronic idiopathic constipation.

Χρόνος Ημιζωής

11±5h

11 ± 5 hours

Σύνδεση Πρωτεϊνών

98%

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Μηχανισμός Δράσης

Tegaserod is a 5-HT<sub>4</sub> receptor partial agonist that binds with high affinity at human 5-HT<sub>4</sub> receptors, whereas it has no …

Οδός Αποβολής

Approximately two-thirds of the orally administered dose of tegaserod is excreted unchanged in the feces, with the remaining one-third excreted in the …

Όγκος Κατανομής

* 368 ± 223 L

Κατηγορίες ATC

Βρείτε τη δραστική μέσα από τις αντίστοιχες κατηγορίες ATC level 5.

Διαθέσιμα Σκευάσματα

Εγκεκριμένα φαρμακευτικά σκευάσματα που περιέχουν TEGASEROD.

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