SUNITINIB
Σουνιτινίμπη
Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant …
Φαρμακολογικό Προφίλ
Περιγραφή & Ένδειξη
Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.
Κύρια Ένδειξη
Χρόνος Ημιζωής
Following administration of a single oral dose in healthy volunteers, the terminal half-lives of sunitinib and its primary active metabolite are approximately 40 to 60 hours and 80 to 110 hours, respectively.
Σύνδεση Πρωτεϊνών
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Μηχανισμός Δράσης
Sunitinib is a small molecule that inhibits multiple RTKs, some of which are implicated in tumor growth, pathologic angiogenesis, and metastatic …
Οδός Αποβολής
Sunitinib is metabolized primarily by the cytochrome P450 enzyme, CYP3A4, to produce its primary active metabolite, which is further metabolized by …
Όγκος Κατανομής
* 2230 L
Κατηγορίες ATC
Βρείτε τη δραστική μέσα από τις αντίστοιχες κατηγορίες ATC level 5.
Διαθέσιμα Σκευάσματα
Εγκεκριμένα φαρμακευτικά σκευάσματα που περιέχουν SUNITINIB.
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