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ATC CODE N04BD02

RASAGILINE

Ρασαγιλίνη

Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.

Chemical structure of RASAGILINE

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases.

Κύρια Ένδειξη

For the treatment of the signs and symptoms of idiopathic Parkinsons disease as initial monotherapy and as adjunct therapy to levodopa.

Χρόνος Ημιζωής

Rasagilinehasameansteady-statehalflifeof3hbutthereisnocorrelationofpharmacokineticswithitspharmacologicaleffectbecauseofitsirreversibleinhibitionofMAO-B.

Rasagiline has a mean steady-state half life of 3 hours but there is no correlation of pharmacokinetics with its pharmacological effect because of its irreversible inhibition of MAO-B.

Σύνδεση Πρωτεϊνών

Plasma protein binding ranges from 88-94% with mean extent of binding of 61-63% to human albumin over the concentration range of 1-100 ng/ml.

Δείτε αναλυτικό φαρμακολογικό προφίλ.

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Μηχανισμός Δράσης

The precise mechanisms of action of rasagiline is unknown. One mechanism is believed to be related to its MAO-B inhibitory activity, which causes an …

Οδός Αποβολής

Rasagiline undergoes almost complete biotransformation in the liver prior to excretion. Glucuronide conjugation of rasagiline and its metabolites, …

Όγκος Κατανομής

* 87 L

Κατηγορίες ATC

Βρείτε τη δραστική μέσα από τις αντίστοιχες κατηγορίες ATC level 5.

ATC Level 5
N04BD02

Ρασαγιλίνη

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Διαθέσιμα Σκευάσματα

Εγκεκριμένα φαρμακευτικά σκευάσματα που περιέχουν RASAGILINE.

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