QUININE
Κινίνη
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before …
Φαρμακολογικό Προφίλ
Περιγραφή & Ένδειξη
An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood. [PubChem]
Κύρια Ένδειξη
Χρόνος Ημιζωής
Approximately 18 hours
Σύνδεση Πρωτεϊνών
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Μηχανισμός Δράσης
The theorized mechanism of action for quinine and related anti-malarial drugs is that these drugs are toxic to the malaria parasite. Specifically, the …
Οδός Αποβολής
Quinine is eliminated primarily via hepatic biotransformation. Approximately 20% of quinine is excreted unchanged in urine.
Όγκος Κατανομής
* 1.43 ± 0.18 L/kg [Healthy Pediatric Controls] * 0.87 ± 0.12 L/kg [P. falciparum Malaria Pediatric Patients] * 2.5 to 7.1 L/kg [healthy subjects who …
Κατηγορίες ATC
Βρείτε τη δραστική μέσα από τις αντίστοιχες κατηγορίες ATC level 5.
Διαθέσιμα Σκευάσματα
Εγκεκριμένα φαρμακευτικά σκευάσματα που περιέχουν QUININE.
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