ATC CODE A07EC03

OLSALAZINE

Ολσαλαζίνη

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. Olsalazine is a derivative of salicylic acid. Inactive by itself (it is a prodrug), it is converted by the bacteria in the colon to mesalamine. Mesalamine works as an anti-inflammatory agent in treating inflammatory diseases of the intestines.

Κύρια Ένδειξη

For the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.

Χρόνος Ημιζωής

Olsalazinehasaneliminationhalf-lifeof0.9h,however,olsalazine-Shasahalf-lifeof7days.

Olsalazine has an elimination half-life of 0.9 hours, however, olsalazine-S has a half-life of 7 days.

Σύνδεση Πρωτεϊνών

Olsalazine and olsalazine-S are more than 99% bound to plasma proteins. Mesalamine (5-ASA) is 74% bound to plasma proteins.

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Μηχανισμός Δράσης

Orally administered olsalazine is converted to mesalamine which is thought to be the therapeutically active agent in the treatment of ulcerative …

Οδός Αποβολής

Approximately 0.1% of an oral dose of olsalazine is metabolized in the liver to olsalazine-O-sulfate (olsalazine-S).The remaining 5-ASA is partially …