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ATC CODE J02AX05

MICAFUNGIN

Μικαφουγκίνη

Micafungin is an antifungal drug. It belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component …

Chemical structure of MICAFUNGIN

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

Micafungin is an antifungal drug. It belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.

Κύρια Ένδειξη

For use in the treatment of candidemia, acute disseminated candidiasis, and certain other invasive <i>Candida</i> infections, as well as esophageal candidiasis, and prophylaxis of <i>Candida</i> infections in patients undergoing hematopoietic stem cell transplantation. Micafungin is also used as an alternative for the treatment of oropharyngeal candidiases and has been used with some success as primary or salvage therapy, alone or in combination with other antifungals, for the treatment of invasive aspergillosis.

Χρόνος Ημιζωής

14-17h

14-17 hours

Σύνδεση Πρωτεϊνών

Highly (>99%) protein bound in vitro, independent of plasma concentrations over the range of 10 to 100 &micro;g/mL. The primary binding protein is albumin; however, micafungin, at therapeutically relevant concentrations, does not competitively displace bilirubin binding to albumin. Micafungin also binds to a lesser extent to a<sub>1</sub>-acid-glycoprotein.

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Μηχανισμός Δράσης

Micafungin inhibits the synthesis of 1,3-b-D-glucan, an essential component of fungal cell walls, which is not present in mammalian cells.

Οδός Αποβολής

Fecal excretion is the major route of elimination (total radioactivity at 28 days was 71% of the administered dose).

Όγκος Κατανομής

* 0.39 ± 0.11 L/kg [adult patients with esophageal candidiasis]

Κατηγορίες ATC

Βρείτε τη δραστική μέσα από τις αντίστοιχες κατηγορίες ATC level 5.

ATC Level 5
J02AX05

Μικαφουγκίνη

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Διαθέσιμα Σκευάσματα

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