Αντιβιοτικά

ATC CODE N07BC02

METHADONE

Μεθαδόνη

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant …

Chemical structure of METHADONE

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Κύρια Ένδειξη

For the treatment of dry cough, drug withdrawal syndrome, opioid type drug dependence, and pain.

Χρόνος Ημιζωής

24-36h

24-36 hours

Σύνδεση Πρωτεϊνών

In plasma, methadone is predominantly bound to α1-acid glycoprotein (85% to 90%).

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Μηχανισμός Δράσης

Methadone is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most prominent of which …

Οδός Αποβολής

The elimination of methadone is mediated by extensive biotransformation, followed by renal and fecal excretion. Unmetabolized methadone and its …

Όγκος Κατανομής

* 1.0 to 8.0 L/kg

Κατηγορίες ATC

Βρείτε τη δραστική μέσα από τις αντίστοιχες κατηγορίες ATC level 5.

Διαθέσιμα Σκευάσματα

Εγκεκριμένα φαρμακευτικά σκευάσματα που περιέχουν METHADONE.

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