ATC CODE M01AG04

MECLOFENAMIC ACID

Μεκλοφεναμικό οξύ

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. [PubChem]

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. [PubChem]

Κύρια Ένδειξη

For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis.

Χρόνος Ημιζωής

Inastudyin10healthysubjectsfollowingasingleoraldosetheapparenteliminationhalf-liferangedfrom0.8to5.3h.MetaboliteI(3-hydroxymethylmetaboliteofmeclofenamicacid)hasameanhalf-lifeofapproximately15h.

In a study in 10 healthy subjects following a single oral dose the apparent elimination half-life ranged from 0.8 to 5.3 hours. Metabolite I (3-hydroxymethyl metabolite of meclofenamic acid) has a mean half-life of approximately 15 hours.

Σύνδεση Πρωτεϊνών

Greater than 99% bound to plasma proteins over a wide drug concentration range.

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Μηχανισμός Δράσης

The mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. Therapeutic action does not result from pituitary-adrenal …