ATC CODE C03AA02

HYDROFLUMETHIAZIDE

Υδροφλουμεθειαζίδιο

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)

Chemical structure of HYDROFLUMETHIAZIDE

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)

Κύρια Ένδειξη

Used as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Also used in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Χρόνος Ημιζωής

Itappearstohaveabiphasicbiologicalhalf-lifewithanestimatedalpha-phaseofabout2handanestimatedbeta-phaseofabout17h

It appears to have a biphasic biological half-life with an estimated alpha-phase of about 2 hours and an estimated beta-phase of about 17 hours

Σύνδεση Πρωτεϊνών

74%

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Μηχανισμός Δράσης

Hydroflumethiazide is a thiazide diuretic that inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the …