ATC CODE V03AB34

FOMEPIZOLE

Φομεπιζόλη

Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial …

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

Κύρια Ένδειξη

Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis

Χρόνος Ημιζωής

Theplasmahalf-lifeofAntizolvarieswithdose,eveninpatientswithnormalrenalfunction,andhasnotbeencalculated.

The plasma half-life of Antizol varies with dose, even in patients with normal renal function, and has not been calculated.

Σύνδεση Πρωτεϊνών

Μ/Δ

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Μηχανισμός Δράσης

Antizol (fomepizole) is a competitive inhibitor of alcohol dehydrogenase. Alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde. …

Οδός Αποβολής

In healthy volunteers, only 1-3.5% of the administered dose of Antizol® (7-20 mg/kg oral and IV) was excreted unchanged in the urine, indicating that …