ATC CODE J01FA13

DIRITHROMYCIN

Διριθρομυκίνη

Dirithromycin is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

Dirithromycin is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Κύρια Ένδειξη

For the treatment of the following mild-to-moderate infections caused by susceptible strains of microorganisms: acute bacterial exacerbations of chronic bronchitis, secondary bacterial infection of acute bronchitis, community-acquired pneumonia, pharyngitis/tonsilitis, and uncomplicated skin and skin structure infections.

Χρόνος Ημιζωής

Themeanplasmahalf-lifeoferythromycylaminewasestimatedtobeabout8h(2to36h),withameanurinaryterminaleliminationhalf-lifeofabout44h(16to65h)inpatientswithnormalrenalfunction.

The mean plasma half-life of erythromycylamine was estimated to be about 8 h (2 to 36 h), with a mean urinary terminal elimination half-life of about 44 h (16 to 65 h) in patients with normal renal function.

Σύνδεση Πρωτεϊνών

15 to 30% for erythromycylamine, the active compound.

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Μηχανισμός Δράσης

Dirithromycin prevents bacteria from growing, by interfering with their protein synthesis. Dirithromycin binds to the 50S subunit of the 70S bacterial …