ATC CODE R05DA09

DEXTROMETHORPHAN

Δεξτρομεθορφάνη

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

The d-isomer of the codeine analog of levorphanol. Dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-methyl-D-aspartate) and acts as a non-competitive channel blocker. It is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity. [PubChem]

Κύρια Ένδειξη

For treatment and relief of dry cough.

Χρόνος Ημιζωής

3-6h

3-6 hours

Σύνδεση Πρωτεϊνών

Μ/Δ

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Μηχανισμός Δράσης

Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the NMDA glutamatergic receptor, it is an agonist to the opioid sigma …