COLCHICINE
Κολχικίνη
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial …
Φαρμακολογικό Προφίλ
Περιγραφή & Ένδειξη
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (periodic disease). [PubChem]
Κύρια Ένδειξη
Χρόνος Ημιζωής
Elimination half-life is approximately 1 hour in healthy subjects, although a study with an extended sampling time reported mean terminal elimination half-life values of approximately 9 to 10.5 hours. Other studies have reported half-life values of approximately 2 hours in patients with alcoholic cirrhosis and approximately 2.5 hours in patients with familial Mediterranean fever.
Σύνδεση Πρωτεϊνών
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Μηχανισμός Δράσης
The precise mechanism of action has not been completely established. In patients with gout, colchicine apparently interrupts the cycle of monosodium …
Οδός Αποβολής
In healthy volunteers (n=12) 40 – 65% of 1 mg orally administered colchicine was recovered unchanged in urine. Enterohepatic recirculation and biliary …
Όγκος Κατανομής
* 5 to 8 L/kg [healthy young volunteers]
Κατηγορίες ATC
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Διαθέσιμα Σκευάσματα
Εγκεκριμένα φαρμακευτικά σκευάσματα που περιέχουν COLCHICINE.
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