ATC CODE C07AB04

ACEBUTOLOL

Ακεβουτολόλη

A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent …

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. [PubChem]

Κύρια Ένδειξη

For the management of hypertension and ventricular premature beats in adults.

Χρόνος Ημιζωής

Theplasmaeliminationhalf-lifeisapproximately3to4h.Thehalf-lifeofitsmetabolite,diacetolol,is8to13h.

The plasma elimination half-life is approximately 3 to 4 hours. The half-life of its metabolite, diacetolol, is 8 to 13 hours.

Σύνδεση Πρωτεϊνών

26%

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Μηχανισμός Δράσης

Acebutolol is a selective β1-receptor antagonist. Activation of β1-receptors by epinephrine increases the heart rate and the blood pressure, …

Οδός Αποβολής

Elimination via renal excretion is approximately 30% to 40% and by non-renal mechanisms 50% to 60%, which includes excretion into the bile and direct …